| Background : |
Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important <br />role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other <br />CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as <br />upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which <br />encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to <br />synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to<br /> the same pathogenetic process that leads to the malignancy. |
