| Catalog #: |
SGA20291
|
| Product Name : |
45570 Monoclonal Antibody |
| Size : |
100ul |
| Price : |
$375 |
| Applications : |
ELISA |
| Reactivity : |
Human |
| Immunogen : |
Purified recombinant fragment of Oct4 (aa193-360) expressed in E. Coli. |
| Host : |
Mouse IgG1 |
| Antibody Type : |
Primary antibody |
| Swissprot : |
Q01860 |
| Clone # : |
1D10H6 |
| WB Predicted band size : |
38.5kDa |
| Data sheet : |
|
| Formulation : |
Ascitic fluid containing 0.03% sodium azide. |
| Storage : |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Aliases : |
OCT3; OTF3; OTF4; MGC22487; POU5F1 |
| Background : |
Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues. |
| Image : |
|
