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Antibody
Catalog #:

SGA20142

Product Name : Cytokeratin 5 Monoclonal Antibody
Size : 100ul
Price : $375
Applications : IHC
Reactivity : Human
Immunogen : Purified recombinant fragment of CK5 expressed in E. Coli.
Host : Mouse IgG1
Antibody Type : Primary antibody
Swissprot : P13647
Clone # : 3E2F1
WB Predicted band size :
Data sheet :
Formulation : Ascitic fluid containing 0.03% sodium azide.
Storage : Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Aliases : K5; DDD; EBS2; KRT5A; KRT5.
Background : CK5 (keratin 5) is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.
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