| Catalog #: |
SGA20064
|
| Product Name : |
ZAP70 Monoclonal Antibody |
| Size : |
100ul |
| Price : |
$375 |
| Applications : |
WB,IHC |
| Reactivity : |
Human |
| Immunogen : |
Purified recombinant fragment of human ZAP70 expressed in E. Coli. |
| Host : |
Mouse IgG1 |
| Antibody Type : |
Monoclonal Antibody |
| Swissprot : |
P43403 |
| Clone # : |
3D2A4 |
| WB Predicted band size : |
70kDa |
| Data sheet : |
|
| Formulation : |
Ascitic fluid containing 0.03% sodium azide. |
| Storage : |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Aliases : |
SRK; STD; TZK |
| Background : |
ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia. |
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