| Catalog #: |
SGA20027
|
| Product Name : |
MCL-1 Monoclonal Antibody |
| Size : |
100ul |
| Price : |
$375 |
| Applications : |
WB,IHC,ICC |
| Reactivity : |
Human |
| Immunogen : |
Purified recombinant fragment of human MCL-1 expressed in E. Coli.<br /> |
| Host : |
Mouse IgG1 |
| Antibody Type : |
Monoclonal Antibody |
| Swissprot : |
Q07820 |
| Clone # : |
8C6D4B1 |
| WB Predicted band size : |
37kDa |
| Data sheet : |
|
| Formulation : |
Purified antibody in PBS containing 0.03% sodium azide. |
| Storage : |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Aliases : |
EAT, MCL1L, MCL1S |
| Background : |
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate. |
| Image : |
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