| Catalog #: |
SGA20011
|
| Product Name : |
IL-10 Monoclonal Antibody |
| Size : |
100uL |
| Price : |
$375 |
| Applications : |
|
| Reactivity : |
Human |
| Immunogen : |
Purified recombinant fragment of human IL-10 expressed in E. Coli. |
| Host : |
Mouse IgG1 |
| Antibody Type : |
Primary antibody |
| Swissprot : |
P22301 |
| Clone # : |
3C12C12 |
| WB Predicted band size : |
|
| Data sheet : |
|
| Formulation : |
Ascitic fluid containing 0.03% sodium azide. |
| Storage : |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Aliases : |
IL10 |
| Background : |
Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by <br />lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-<br />regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on <br />macrophages. It also enhances B cell survival, proliferation, and antibody production. This <br />cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling <br />pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. |
| Image : |
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